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MOSCOW - Novichok, a deadly nerve agent that has left Russian opposition politician Alexei Navalny in a coma and nearly killed a former Russian spy and his daughter in 2018, was the product of a highly secretive Soviet chemical weapons program. Here is a look at the agent and the history of its development. 

How lethal is Novichok? 

Novichok, the nerve agent used in the attack that nearly killed former spy Sergei Skripal and his daughter, Yulia, in the English city of Salisbury on March 4, 2018, has been described as much deadlier than any U.S. equivalents. 

FILE - The forensic tent, covering the bench where Sergei Skripal and his daughter Yulia were found, is repositioned by officials in protective suits in the center of Salisbury, Britain, March 8, 2018.

Just a few milligrams of the odorless liquid — the weight of a snowflake — are enough to kill a person within minutes. The agent could be diluted to the desired concentration and added to food or drink, or applied to surfaces or clothes. 

Scientists say the nerve agent could remain deadly for a long time — even if a few tiny drops are left in a syringe or impregnated into wood or fabric. 

In the Salisbury attack, it was sprayed on the front door of Skripal's house after being smuggled into Britain in a counterfeit Nina Ricci perfume bottle. The Skripals spent weeks in critical condition before recovering, and a local woman died after being exposed to the bottle, which was found by her boyfriend. 

What do the Russians say about Novichok poisonings?

Russia fiercely denied British accusations over the Skripals' poisoning, accusing London and other Western nations of using the incident to fan an anti-Russian campaign. It has followed the same path of denial in this summer's Navalny poisoning. 

German Chancellor Angela Merkel speaks to media during a statement about latest developments in the case of Russian opposition leader Alexei Navalny at the chancellery in Berlin, Germany, Sept. 2, 2020.

German Chancellor Angela Merkel on Wednesday called Navalny's poisoning an attempted murder that aimed to silence one of Putin's fiercest critics and called for a full investigation, saying "there are very serious questions now that only the Russian government can answer, and must answer." 

Russia, however, has demanded that Germany share its data backing up its conclusion that Navalny was poisoned and has called for a joint investigation effort. 

President Vladimir Putin's spokesman, Dmitry Peskov, insisted Thursday that "there is no reason to accuse the Russian state" over the poisoning. He said Moscow expects Berlin to provide information that would help a Russian probe into the cause of Navalny's illness, and that Russia doctors in Siberia, where Navalny was taken after he fell ill on Aug. 20, found no evidence of poisoning. 

Sergei Naryshkin, the head of the Russian Foreign Intelligence Service, even claimed it can't be excluded that Navalny's poisoning was a provocation of Western intelligence agencies. 

When was Novichok designed?

The Soviet program to design a new generation of chemical weapons began in the 1970s to counter the latest U.S. chemical weapons. 

Soviet leaders wanted the equivalent of U.S. binary weapons — agents made up of relatively harmless components that turn deadly when mixed, making them easier to operate than regular chemical weapons. While Novichok class poisons were highly lethal, the program was only partly successful, as some of the components were as toxic as the military-grade nerve agents. 

The Soviet leadership eventually lost interest in chemical weapons. Novichok-class agents only were manufactured in lab quantities. Vladimir Uglev, a top scientist in the program, has estimated about 100 kilograms (220 pounds) were made. 

Is it possible to trace Novichok's source?

Russian experts who have worked on the Novichok class of agents have warned it may never be possible to determine the nerve agent's origin. 

FILE - German army emergency personnel load into their ambulance the stretcher that was used to transport Russian opposition figure Alexei Navalny on at Berlin's Charite hospital, Aug. 22, 2020.

To determine what specific lab produced a given sample of Novichok, it's necessary to find an identical specimen from the same batch — an impossible task. 

Facing accusations for the Skripals's poisoning, Russia has charged that the U.S., Britain and other Western countries had acquired the expertise to make the nerve agent and that the Novichok used in that attack could have come from them. 

Could it fall into the wrong hands? 

The main Soviet research center that designed the Novichok-class agents was in Shikhany, a town in southwestern Russia. It was one of the "closed cities" isolated by the KGB. The sprawling facility also housed chemical depots and a military firing range, where nerve agents were tested throughout the Cold War. 

Some Novichok-related research also was conducted at a main Moscow research center, which shared samples with other labs across the Soviet Union. 

Despite the U.S. oversight to dismantle Russia's chemical arsenals after the Soviet collapse, scientists involved in the program said they couldn't exclude that some lab workers might have been tempted to sell toxic substances amid the economic and political turmoil in the 1990s. 

Murky status 

Moscow said in 2017 it completed the destruction of 40,000 metric tons of chemical weapons left over from the Soviet era, an effort that spanned two decades under close international oversight. 

The Novichok-class agents weren't originally mentioned in the Chemical Weapons Convention, an international document that outlawed chemical weapons. 

Last year, however, they were added to the list of chemicals that require special verification measures under the treaty's provisions. The move came after the 2018 Salisbury attack and marked the first time the list had been updated.